Piedmont is a city in Calhoun and Cherokee counties in the U.S. state of Alabama. The population was 4,400 at the 2020 census. It is include…Piedmont is a city in Calhoun and Cherokee counties in the U.S. state of Alabama. The population was 4,400 at the 2020 census. It is included in the Anniston-Oxford, Alabama Metropolitan Statistical Area.