The Supreme Court will hear oral arguments Wednesday over Tennessee’s ban on gender-affirming care for minors, a landmark case that will have implications nationwide as Republicans have increasingly targeted transgender rights and enacted bans on healthcare for minors across the country.

The Supreme Court heard arguments on Wednesday in just its second major transgender rights case, a challenge to a Tennessee law that bans gender-affirming care for minors. The nation’s top court will weigh whether Tennessee’s law violates the equal protection clause of the 14th Amendment,

The Supreme Court is set to hear the first-ever case on the legality of bans targeting transgender procedures for minors.