The Buffalo Bills face a tough challenge against the 49ers in Week 13, but the good news is that Josh Allen and Sean ...

The results were ugly for the San Francisco 49ers last week against the Green Bay Packers without starting quarterback Brock ...

The Kansas City Chiefs defeated the Las Vegas Raiders, 19-17, in the NFL’s second-annual Black Friday game to become the ...

The Bills are activating Matt Milano (biceps) off injured reserve and the linebacker will make his long-awaited return on ...

SportsLine's model has simulated San Francisco vs. Buffalo on Sunday Night Football 10,000 times and revealed its SNF picks ...

The Buffalo Bills played the Kansas City Chiefs in their last game before heading into the bye week. They pulled off the ...

And if the Chiefs game is any indication of what could be, the Bills' interior defensive line has a chance to be as equally ...

Running back Christian McCaffrey says the San Francisco 49ers are “hungry” to make a playoff push even with the defending NFC ...

Following their high-profile victory over the AFC-leading Chiefs, the Bills went off the NFL radar for their much-needed Week ...

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.

Analyzing Sunday’s San Francisco 49ers at Buffalo Bills odds and lines, with expert NFL picks and predictions.

San Francisco 49ers vs Buffalo Bills showdown with essential stats, lineup predictions and injury updates you won’t want to ...