The Buffalo Bills will play the San Francisco 49ers at home at Highmark Stadium on "Sunday Night Football" in Week 13. The Bills (9-2) are looking to build on a six-game win streak, while the 49ers (5-6) have lost their last two.

Watch out for the tables on "Sunday Night Football." The nightcap of Sunday's action will be in northern New York with the Buffalo Bills (9-2) hosting the San Francisco 49ers (5-6). San Francisco has been up and down all season, but the Super Bowl hangover ...

Bad news for the 49ers. Brock Purdy still isn't ready to resume throwing. Technically, he threw one pass on Wednesday -- a screen pass that float

The San Francisco 49ers are reeling and now head to Buffalo for a prime time game. Will they have their starting QB back in the fold?

San Francisco 49ers quarterback Brock Purdy was limited with the right shoulder injury that sidelined him last week and there is growing concern about the long-term status of left tackle Trent Williams.

San Francisco 49ers linebacker Fred Warner says he has been playing through a fractured bone in his ankle since Week 4. Warner suffered the injury

San Francisco 49ers star linebacker Fred Warner revealed that he has been playing through a broken bone in his ankle since September.

San Francisco 49ers star Fred Warner told reporters Wednesday that he fractured an ankle on Oct. 29 and has been receiving painkilling injections in order to play.