The Buffalo Bills might have a chance to clinch the AFC East on Sunday night when they battle the injury-decimated San ...

Former Buffalo Bills defensive end Leonard Floyd spoke about facing his old team on Sunday night with the San Francisco 49ers ...

See who's in and who's out for the Week 13 matchup between the Buffalo Bills and San Francisco 49ers on December 1, 2024.

Brock Purdy missed the 49ers' last game against the Packers, but the Bills are preparing as if he's playing on Sunday night.

The 49ers are welcoming Brock Purdy back to practice today after shoulder soreness kept him out of Sunday’s loss at Green Bay.

SANTA CLARA — While Brock Purdy resumed practicing through a shoulder issue and Dre Greenlaw made a much-anticipated debut ...

All six of the NFL teams playing on Thanksgiving will be without critical players. The Chicago Bears will be without center ...

Bad news for the 49ers. Brock Purdy still isn't ready to resume throwing. Technically, he threw one pass on Wednesday -- a ...

"We're just going to keep chopping wood," said running back Christian McCaffrey, as more 49ers stars grapple with ...

The San Francisco 49ers are reeling and now head to Buffalo for a prime time game. Will they have their starting QB back in ...

Brock Purdy was listed as limited for Wednesday's practice by San Francisco 49ers head coach Kyle Shanahan, suggesting some ...

The banged-up San Francisco 49ers received some positive news on Wednesday. Per ESPN's Nick Wagoner, 49ers head coach Kyle ...