The San Francisco 49ers are preparing for their Week 13 contest against the Buffalo Bills on Sunday at Highmark Stadium in ...

The 49ers listed Brock Purdy as a limited participant while Nick Bosa and Trent Williams were among those not practicing ...

The Buffalo Bills are in great shape heading down the stretch of this 2024 NFL regular season. Coming out of their ...

San Francisco 49ers defensive end Nick Bosa missed Wednesday's practice as the team began preparations for Sunday's game ...

You can listen on SiriusXM satellite radio on channel 225 (Bills feed) and channel 226 (49ers feed), and on traditional radio ...

In a season where running backs are thriving in the NFL, the 49ers hope to get Christian McCaffrey back on track.

Watch out for the tables on "Sunday Night Football." The nightcap of Sunday's action will be in northern New York with the ...

All-Pro linebacker Matt Milano and breakout rookie receiver Keon Coleman both practiced for the Bills on Wednesday. Milano ...

Buffalo Bills Coach Sean McDermott discusses winter weather ahead of their matchup against the San Francisco 49ers this ...

Wide receiver Chris Conley, linebacker Curtis Robinson and more San Francisco 49ers players shared what they're most grateful ...

San Francisco 49ers star Deebo Samuel had a blunt reaction when asked about his low numbers to begin this season.

Former Buffalo Bills defensive end Leonard Floyd spoke about facing his old team on Sunday night with the San Francisco 49ers ...