The Buffalo Bills will host the San Francisco 49ers at Highmark Stadium in Orchard Park, New York, on Sunday, December 1, at ...

The Buffalo Bills will look to clinch the AFC East on Sunday with a win against the San Francisco 49ers in what's expected to ...

The San Francisco 49ers are making changes to their WR group ahead of an important road trip to face the Buffalo Bills.

Running back Christian McCaffrey says the San Francisco 49ers are “hungry” to make a playoff push even with the defending NFC ...

The San Francisco 49ers (5-6) try to salvage their season against the Buffalo Bills (9-2) on Sunday Night Football. Kickoff ...

Discover the greatest RBs in San Francisco 49ers history: from Super Bowl heroes to game-changing performers, find out who ...

as the Bills host the San Francisco 49ers. This is the fifth time the Bills are playing in prime-time this year and they are ...

Watching NFL games, including Fox broadcasts, is simple with Hulu + Live TV, which includes 90 channels, unlimited DVR ...

Two words can sum up the Week 12 matchup between the visiting San Francisco 49ers and the host Green Bay Packers: utter ...

The 49ers travel to Buffalo to take on the AFC East-leading Buffalo Bills. Check out our best bet for the game ...

Watch out for the tables on "Sunday Night Football." The nightcap of Sunday's action will be in northern New York with the ...

NFL Week 13 odds, picks, predictions, TV and streaming information for Sunday Night Football game between the San Francisco ...