San Francisco has been up and down all season, but the Super Bowl hangover appears to be happening after the 49ers got ...

San Francisco played without four key players - quarterback Brock Purdy, left tackle Trent Williams, defensive end Nick Bosa ...

Soon, quarterback Brock Purdy is likely to command a $50 million annual pay raise, and if the 49ers do extend him, they'll ...

NFL Week 13 odds, picks, predictions, TV and streaming information for Sunday Night Football game between the San Francisco ...

San Francisco 49ers three-time Super Bowl champion has suddenly passed away at 80, the team announced on Thursday.

How have Super Bowl odds changed over the last week? Let's take a look at the most recent sports betting odds for Super Bowl ...

The rivalry history is about as rich as it can be between two teams from opposite divisions, and the Packers will meet the ...

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

Discover the greatest RBs in San Francisco 49ers history: from Super Bowl heroes to game-changing performers, find out who ...

Sunday's loss to the Seahawks was another offensive slog for a team that isn't looking very Super Bowl-hopeful so far this ...

If it wasn't clear before the Week 11 loss to the Seattle Seahawks, it is definitely clear now. The San Francisco 49ers are hungover from their Super Bowl loss ...

What to expect from Sunday Night Football's 49ers vs. Bills matchup. This is one of those games that feels like Buffalo's to ...