The 49ers have dealt with injuries to key players all season. Brandon Aiyuk injured his knee, Brock Purdy missed last week's game, and Fred Warner has a lingering ankle issue.

The San Francisco 49ers are 5-6 entering their matchup with the Buffalo Bills on Sunday, and an NFL executive called out 49ers HC Kyle Shanahan for mishandling late-game situations. Colin Cowherd discusses this criticism and if it’s the biggest issue the 49ers have right now.

We thought San Francisco was poised for a massive second-half run after the Week 9 bye with Christian McCaffrey back, but the 49ers haven't looked good over their last three contests.  It wasn't a surprise the 49ers fell to the Green Bay Packers on Sunday with so many key contributors out.

One NFL team executive believes the San Francisco 49ers' 5-6 record is partially a product of Kyle Shanahan's coaching. "It's a combination of injuries

Who plays whom in NFL Week 13? Take a look at the 16 games on the Week 13 NFL schedule this week, starting with three games on Thanksgiving (Chicago Bears vs Detroit Lions, New York Giants vs Dallas Cowboys,

Christian McCaffrey and the 49ers travel to Buffalo to take on Josh Allen and the Bills for Sunday Night Football. Live coverage begins at 7 PM ET on NBC and Peacock.

It’s Week 13 in the NFL, and the Buffalo Bills are preparing to host the San Francisco 49ers on Sunday Night Football at 8:20 p.m. Buffalo (9-2) enters the contest having won six straight and is coming off a bye week. Meanwhile, San Francisco (5-6) has dropped two straight and three of five as injuries continue to pile up.

Bills' QB Josh Allen is the current favorite for MVP. Expectations aren't something I like to make a habit. However, it's hard not to expect the best from Allen and the Bills this week. Beating the Chiefs the way they did helped them check off that confidence box, and they did it on their 12th straight week of football.

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NFL Week 13 odds, picks, predictions, TV and streaming information for Sunday Night Football game between the San Francisco 49ers and Buffalo Bills.

The San Francisco 49ers face a tough challenge on Sunday, traveling to Wisconsin to take on the Green Bay Packers.