The National Weather Service has extended its "lake effect snow warning" in Buffalo through Monday at 7 p.m. ET, with ...

The San Francisco 49ers (5-6) try to salvage their season against the Buffalo Bills (9-2) on Sunday Night Football. Kickoff ...

The results were ugly for the San Francisco 49ers last week against the Green Bay Packers without starting quarterback Brock ...

"Sunday Night Football" in Week 13 sees the San Francisco 49ers taking on the Buffalo Bills. Here's the latest on a snowy ...

They don't get a divisional opponent in Week 13, but a struggling San Francisco 49ers team still possesses plenty of firepower for Buffalo to be concerned with as it starts December. Here are five ...

Preview the Week 13 matchup between the Buffalo Bills and San Francisco 49ers with predictions, odds, over/under, spread, ...

Heads have already started to roll at the San Francisco 49ers. Entering the final third of the regular season, management ...

NFL fans are in for a remarkable showdown on Sunday night when the San Francisco 49ers travel to Highmark Stadium to take on ...

The San Francisco 49ers were among the Super Bowl favorites heading into the season, but they find themselves below the .500 ...

The Buffalo Bills have activated Matt Milano from injured reserve, putting the starting linebacker in position to play Sunday ...

San Francisco's starting quarterback missed last week's loss to the Packers. Here's the latest on whether he'll play in primetime on Sunday.

Buffalo Bills quarterback Josh Allen could become his team's sole all-time leading touchdown scorer in Week 13.