Tight end Kincaid will miss a second consecutive game when the Bills host the Niners at Highmark Stadium on Sunday.

The San Francisco 49ers will take on the Buffalo Bills in the Week 13 edition of NBC's "Sunday Night Football." What to know ...

The NFL's two best running backs meet Sunday in a potential Super Bowl preview. Seattle, Arizona and San Francisco also have ...

NFL fans who tuned in to watch Tom Brady tuck into a Turducken live on Thanksgiving will have to do without the New England ...

Neil Reynolds, Jeff Reinebold and Phoebe Schecter discuss San Franciscos playoff prospects on the Inside The Huddle Pofcast; ...

"Sunday Night Football" in Week 13 sees the San Francisco 49ers taking on the Buffalo Bills. Here's the latest on a snowy ...

As a group, the Bills’ offense ranks second to the Ravens in the same statistical category and Top 5 overall in Rush EPA – a ...

As the 49ers prepare for their Week 13 matchup against the Bills, Brock Purdy will be the signal caller after being listed as ...

The San Francisco 49ers saw their playoff chances plummet following consecutive losses to the Seattle Seahawks and Green Bay ...

On Saturday night, ESPN's Adam Schefter reported that San Francisco 49ers quarterback Brock Purdy, officially listed as ...

When Brock Purdy started looking visibly uncomfortable during the fourth quarter of his Week 11 showdown against the Seattle ...

The Bills welcome the 49ers to upstate New York on Sunday Night Football in Week 13. Buffalo (9-2) continues its quest to ...