Former Buffalo Bills defensive end Leonard Floyd spoke about facing his old team on Sunday night with the San Francisco 49ers ...

The Buffalo Bills might have a chance to clinch the AFC East on Sunday night when they battle the injury-decimated San ...

See who's in and who's out for the Week 13 matchup between the Buffalo Bills and San Francisco 49ers on December 1, 2024.

Brock Purdy missed the 49ers' last game against the Packers, but the Bills are preparing as if he's playing on Sunday night.

All six of the NFL teams playing on Thanksgiving will be without critical players. The Chicago Bears will be without center ...

Bad news for the 49ers. Brock Purdy still isn't ready to resume throwing. Technically, he threw one pass on Wednesday -- a ...

The San Francisco 49ers are reeling and now head to Buffalo for a prime time game. Will they have their starting QB back in ...

The San Francisco 49ers are preparing for their Week 13 contest against the Buffalo Bills on Sunday at Highmark Stadium in ...

The banged-up San Francisco 49ers received some positive news on Wednesday. Per ESPN's Nick Wagoner, 49ers head coach Kyle ...

LB Fred Warner, WR Deebo Samuel Sr., RB Christian McCaffrey and DL Nick Bosa identified key areas for improvement as the team ...

The 49ers have revealed their latest injury report from Wednesday’s practice before their Sunday Night Football tilt against ...

San Francisco 49ers quarterback Brock Purdy was limited with the right shoulder injury that sidelined him last week and there ...