LCGC International spoke to Michelle Klein from the Faculty of Chemistry of the University of Duisburg-Essen (Essen, Germany) about how, by using the green analytical chemistry tool Analytical GREEnness (AGREE) and the white analytical chemistry (WAC) framework, her team was able to conduct a comparative analysis of gas chromatography-tandem mass spectrometry (GC–MS/MS), liquid ...

Jan 1, 2019 · Founded in 1983, LCGC International is the leading provider of digital and print content to the separation science market, enhancing the productivity, efficiency, and the overall value of separation techniques globally. With our commitment to editorial excellence, we have pioneered innovation across a broad portfolio of digital and print platforms.

Practical advice, tutorials, and peer-reviewed research on liquid chromatography (HPLC), gas chromatography (GC), mass spectrometry (MS) and related techniques.

Feb 1, 2009 · The concept of the limit of detection (LOD) has been, and still is, one of the most controversial in analytical chemistry. The multiple definitions and calculation methods proposed have contributed to this situation. Although in the last years, several international organizations, such as ISO or IUPAC, have tried to reach a consensus in their definitions and have issued guidelines for the ...

Practical advice, tutorials, and peer-reviewed research on liquid chromatography (HPLC), gas chromatography (GC), mass spectrometry (MS) and related techniques.

Practical advice, tutorials, and peer-reviewed research on liquid chromatography (HPLC), gas chromatography (GC), mass spectrometry (MS) and related techniques.

Oct 1, 2019 · Requirements and Desirable Characteristics of UV Detectors. Table II summarizes the requirements and desirable characteristics of a modern UV detector (VWD or DAD), followed by a discussion of historical perspectives, optical designs, operating principles, and common operation and maintenance procedures.

Jan 1, 2024 · Gas chromatography is a premier technique for quantitative analysis. As gas chromatographs have become simpler to use and data systems more powerful, much of the data processing involved in delivering quantitative results now happens in the background and is seemingly invisible to the user. In this installment, we will review the calibration techniques used with gas chromatography.

Jun 10, 2024 · Case Studies from an Early-Phase Small-Molecule Development Project: Background Information. A case study from my experience as a chemistry, manufacturing, and controls (CMC) analytical team lead supporting an early-phase small-molecule oncology drug development project was used to illustrate how CoAs expedite quality documentation of testing methods and results.

Nov 1, 2019 · where â s is the spacing between the apex of two signals with respect to their average baseline width, w av = (w 1 +w 2)/2.This equation is applicable to all signal shapes; however, the significance of the calculated value depends …